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E-GEOD-16752

Title: Rat liver. Control vs. Chemical treated: time course
Organism(s): Rattus norvegicus
Description: This SuperSeries is composed of the following subset Series: GSE16340: Rat liver. Control vs. Chemical treated, 3 days GSE16394: Rat liver. Control vs. Chemical treated, 28 days GSE16743: Rat liver: Control vs. Chemical treated, 14 days Refer to individual Series
Design(s): transcription profiling by array
Experimental factor(s):
compound
89 recorded
alpha-hexachlorocyclohexane vehicle control condition 2,6-Diaminotoluene (CHEMBL1489438) hexachlorobenzene glutaraldehyde 2-methyl-1,4-phenylenediamine Sodium benzoate paracetamol 3-chloro-p-toluidine 7,12-Dimethylbenz aanthracene (DMBA) L-ascorbic acid 2-Chloro-p-phenylenediamine SO4 (CHEMBL1391326) D,L-Menthol (CHEMBL256087) D-mannitol N-nitrosodimethylamine methapyrilene Dichlorodiphenyltrichloroethane (DDT) 4-(Chloroacetyl)acetanilide (CHEMBL1408847) Aldrin 8-Hydroxyquinoline diethylstilbestrol quinoline phenobarbital phenytoin 17alpha-ethynylestradiol 4-Nitroanthranilic acid N-nitrosomorpholine 1,4-dichlorobenzene acetamide 2-chloroethanol tetrachloromethane 4-Dimethylaminoazobenzene (DAB) 2-nitropropane 4-Nitroquinoline-1-oxide diethylhexyl phthalate 2-acetylaminofluorene Lindane caprolactam indomethacin 1,4-dioxane ethyl nitrosourea acetylsalicylic acid urethane 1-Chloro-2-propanol (CHEMBL1361129) p-Phenylenediamine 2HCl Tris(2-chloroethyl)phosphate methyl carbamate dieldrin trichloroethylene D,L-Ethionine clofibrate D-Limonene 4-Aminoazobenzene (AAB) 4-Nitro-o-phenylenediamine benzoin Tetrachloroethylene N-nitrosodiethylamine Methyldimethylaminoazobenzene phthalamide furan chlorendic acid 4-acetylaminofluorene 1-Nitropyrene (CHEMBL167395) 2,4-diaminotoluene 2-Nitro-p-phenylenediamine (CHEMBL353971) lithocholic acid Safrole chloroform 1-nitronaphthalene 2-Chloromethylpyridine HCl (CHEMBL1421966) tannic acid 3-methylcholanthrene O-nitrotoluene PhIP (CASRN 105650-23-5) Benzo apyrene (BP) thioacetamide Benz aanthracene (BA) Di(2-ethylhexyl)adipate (DEHA) (CHEMBL1414950) N-nitrosopiperidine iodoform pentachloroethane 1-Nitropropane (CHEMBL1449933) trichloroacetic acid Butylated Hydroxyanisole alpha-Tocopherol (Vitamin E) MeIQx (CASRN 77500-04-0) quercetin N-methyl-N'-nitro-N-nitrosoguanidine methyleugenol
treatment
4 recorded
28 day not specified 14 day 3 day
age
1 recorded
5 weeks
vehicle
9 recorded
Corn oil Saline Water MC 1% CMC Water (PH4) Gum arabic 0.1% CMC 0.5% MC
dose
33 recorded
20mg/kg/day 0mg/kg/day 10mg/kg/day 5mg/kg/day 50mg/kg/day 1000mg/kg/day 700mg/kg/day 300mg/kg/day 1mg/kg/day 100mg/kg/day 0.2mg/kg/day 25mg/kg/day 250mg/kg/day 0.3mg/kg/day 160mg/kg/day 0.5mg/kg/day 1180mg/kg/day 40mg/kg/day 2mg/kg/day 6mg/kg/day 375mg/kg/day 3mg/kg/day 27mg/kg/day 80mg/kg/day 60mg/kg/day 88mg/kg/day 500mg/kg/day 30mg/kg/day 90mg/kg/day 150mg/kg/day 15mg/kg/day 200mg/kg/day 750mg/kg/day
Publication(s): Matsumoto H, Yakabe Y, Saito K, Sumida K, Sekijima M, Nakayama K, Miyaura H, Saito F, Otsuka M, Shirai T.
Discrimination of carcinogens by hepatic transcript profiling in rats following 28-day administration. PubMed:20011461

Sample attribute(s):
Material Type
1 recorded
total RNA
sex
1 recorded
male
compound
89 recorded
alpha-hexachlorocyclohexane vehicle control condition 2,6-Diaminotoluene (CHEMBL1489438) hexachlorobenzene glutaraldehyde 2-methyl-1,4-phenylenediamine Sodium benzoate paracetamol 3-chloro-p-toluidine 7,12-dimethyltetraphene L-ascorbic acid 2-Chloro-p-phenylenediamine SO4 (CHEMBL1391326) D,L-Menthol (CHEMBL256087) D-mannitol N-nitrosodimethylamine methapyrilene DDT 4-(Chloroacetyl)acetanilide (CHEMBL1408847) Aldrin (309-00-2) quinolin-8-ol diethylstilbestrol quinoline phenobarbital phenytoin 17alpha-ethynylestradiol 4-Nitroanthranilic acid N-Nitrosomorpholine (59-89-2) 1,4-dichlorobenzene acetamide 2-chloroethanol tetrachloromethane 4-Dimethylaminoazobenzene (DAB) 2-nitropropane 4-nitroquinoline N-oxide bis(2-ethylhexyl) phthalate 2-acetamidofluorene gamma-hexachlorocyclohexane caprolactam indomethacin 1,4-dioxane N-ethyl-N-nitrosourea acetylsalicylic acid urethane 1-chloropropan-2-ol 1,4-phenylenediamine tris(2-chloroethyl) phosphate Methyl carbamate (CHEMBL1085707) dieldrin trichloroethene D,L-Ethionine clofibrate (4R)-limonene 4-(phenylazo)aniline 4-nitro-1,2-phenylenediamine benzoin tetrachloroethene N-nitrosodiethylamine 3'-Methyl-4-dimethylaminoazobenzene (3'-Me-DAB) (CHEMBL263116) phthalamide furan Chlorendic acid (115-28-6) 4-Acetylaminofluorene (4-AAF) (CAS 28322-02-3) 1-Nitropyrene (CHEMBL167395) 2,4-diaminotoluene 2-Nitro-p-phenylenediamine (CHEMBL353971) lithocholic acid Safrole (CHEMBL242273) chloroform 1-nitronaphthalene 2-Chloromethylpyridine HCl (CHEMBL1421966) tannic acid 3-methylcholanthrene 2-nitrotoluene PhIP (CASRN 105650-23-5) Benzo apyrene (BP) thioacetamide tetraphene Di(2-ethylhexyl)adipate (DEHA) (CHEMBL1414950) N-Nitrosopiperidine (CHEMBL165244) iodoform Pentachloroethane (CHEMBL350040) 1-Nitropropane (CHEMBL1449933) trichloroacetic acid Butylated hydroxyanisole (BHA) (25013-16-5) alpha-tocopherol MeIQx (CASRN 77500-04-0) quercetin N-methyl-N'-nitro-N-nitrosoguanidine O-methyleugenol
strain
1 recorded
Fischer 344
treatment
3 recorded
28 day 14 day 3 day
age
1 recorded
5 week
tissue
1 recorded
liver
Label
2 recorded
Cy3 Cy5
Organism
1 recorded
Rattus norvegicus
administration
1 recorded
gavage
dose
33 recorded
20mg/kg/day 0mg/kg/day 10mg/kg/day 5mg/kg/day 50mg/kg/day 1000mg/kg/day 700mg/kg/day 300mg/kg/day 1mg/kg/day 100mg/kg/day 0.2mg/kg/day 25mg/kg/day 250mg/kg/day 0.3mg/kg/day 160mg/kg/day 0.5mg/kg/day 1180mg/kg/day 40mg/kg/day 2mg/kg/day 6mg/kg/day 375mg/kg/day 3mg/kg/day 27mg/kg/day 80mg/kg/day 60mg/kg/day 88mg/kg/day 500mg/kg/day 30mg/kg/day 90mg/kg/day 150mg/kg/day 15mg/kg/day 200mg/kg/day 750mg/kg/day
Contact(s): Hiroshi Matsumoto
Release Date: 6/23/2009
Submission Date:
Metadata Downloads Download Study Metadata as ISAtabDownload Study Metadata as ISAtab
Assay Downloads
transcription profiling using DNA microarray
1041 assays