| Title: |
Transcriptional profiling of patients with osteoarthritis or rheumatoid arthritis, compared to normal controls. Patients are taking a mixture of NSAIDs, DMARDs (disease-modifying antirheumatic drugs), and steroids. Some samples are pools.[original title: Transcription profiling of human synovial samples from patients with osteoarthritis, rheumatoid arthritis vs controls treated with various drug regimes to characterise RA at the molecular level and to uncover key pathomechanisms]
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| Organism(s): |
Homo sapiens
|
| Description: |
Synovial tissue collected during synovectomy. Six samples are from individual patients (individual), and nine are pooled samples from 2-4 individuals (pooled), some of mixed sex and drug regimen. Individual characteristics are indicated wherever possible. Note: Table 1 in the paper provides additional clinical characterization of the samples. [original description: Rheumatoid arthritis (RA) is a chronic, inflammatory joint disease of unknown etiology and pronounced inter-patient heterogeneity. To characterize RA at the molecular level and to uncover key pathomechanisms, we performed whole-genome gene expression analyses. Synovial tissues from rheumatoid arthritis patients were compared to those from osteoarthritis patients and to normal donors. Experiment Overall Design: Two disease conditions (rheumatoid arthritis and osteoarthritis) in comparison to normal donors were investigated. For the two disease groups samples derived from three individual patients and two pools of patients were hybridised.]
|
| Design(s): |
in_vivo_design, disease_state_design, co-expression_design, transcription profiling by array
|
| Experimental factor(s): |
|
| treatment1
2
recorded
|
|
|
|
none
non-steroidal anti-inflammatory drug
|
| treatment2
1
recorded
|
|
|
|
Antirheumatic Agents
|
| treatment3
1
recorded
|
|
|
|
steroid
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| diseasestate
3
recorded
|
|
|
|
Healthy_control_subjects
rheumatoid arthritis
osteoarthritis
|
|
| Publication(s): |
Ungethuem U, Haeupl T, Witt H, Koczan D, Krenn V, Huber H, von Helversen TM, Drungowski M, Seyfert C, Zacher J, Pruss A, Neidel J, Lehrach H, Thiesen HJ, Ruiz P, Bläss S.
Molecular signatures and new candidates to target the pathogenesis of rheumatoid arthritis.
PubMed:20858714
|
| Sample attribute(s): |
|
| Material Type
2
recorded
|
|
|
|
synthetic_RNA
total_RNA
|
| OrganismPart
1
recorded
|
|
|
|
synovial tissue
|
| age
15
recorded
|
|
|
|
69, 64, 75, 58 years
58, unknown years
51, 84, 74 years
63 years
58, 77 years
86 years
32, 47, 75 years
69 years
45, 81 years
46, unknown years
49 years
44 years
58, 58, 57, unknown years
60, 77 years
68 years
|
| sex2
2
recorded
|
|
|
|
male
unknown sex
|
| DiseaseState
3
recorded
|
|
|
|
Healthy_control_subjects
rheumatoid arthritis
osteoarthritis
|
| sample type
2
recorded
|
|
|
|
postmortem
Surgical excision sample
|
| Label
1
recorded
|
|
|
|
biotin
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| Individual
15
recorded
|
|
|
|
pooled material donor 1
pooled material donor 5
pooled material RA B
individual sample RA z
pooled material OA B
individual sample OA x
pooled material donor 3
individual sample OA y
pooled material RA A
pooled material donor 4
individual sample RA y
individual sample RA x
pooled material donor 2
pooled material OA A
individual sample OA z
|
| organism
1
recorded
|
|
|
|
Homo sapiens
|
| sex1
2
recorded
|
|
|
|
female
male
|
|
| Contact(s): |
Ute Ungethuem
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| Release Date: |
11/11/2007
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| Submission Date: |
|
| Metadata Downloads |
Download Study Metadata as ISAtabDownload Study Metadata as ISAtab
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| Assay Downloads |
| transcription profiling using DNA microarray
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| 15 assays |
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