Title: Transcriptional profiling of patients with osteoarthritis or rheumatoid arthritis, compared to normal controls. Patients are taking a mixture of NSAIDs, DMARDs (disease-modifying antirheumatic drugs), and steroids. Some samples are pools.[original title: Transcription profiling of human synovial samples from patients with osteoarthritis, rheumatoid arthritis vs controls treated with various drug regimes to characterise RA at the molecular level and to uncover key pathomechanisms]
Organism(s): Homo sapiens
Description: Synovial tissue collected during synovectomy. Six samples are from individual patients (individual), and nine are pooled samples from 2-4 individuals (pooled), some of mixed sex and drug regimen. Individual characteristics are indicated wherever possible. Note: Table 1 in the paper provides additional clinical characterization of the samples. [original description: Rheumatoid arthritis (RA) is a chronic, inflammatory joint disease of unknown etiology and pronounced inter-patient heterogeneity. To characterize RA at the molecular level and to uncover key pathomechanisms, we performed whole-genome gene expression analyses. Synovial tissues from rheumatoid arthritis patients were compared to those from osteoarthritis patients and to normal donors. Experiment Overall Design: Two disease conditions (rheumatoid arthritis and osteoarthritis) in comparison to normal donors were investigated. For the two disease groups samples derived from three individual patients and two pools of patients were hybridised.]
Design(s): in_vivo_design, disease_state_design, co-expression_design, transcription profiling by array
Experimental factor(s):
2 recorded
none non-steroidal anti-inflammatory drug
1 recorded
Antirheumatic Agents
1 recorded
3 recorded
Healthy_control_subjects rheumatoid arthritis osteoarthritis
Publication(s): Ungethuem U, Haeupl T, Witt H, Koczan D, Krenn V, Huber H, von Helversen TM, Drungowski M, Seyfert C, Zacher J, Pruss A, Neidel J, Lehrach H, Thiesen HJ, Ruiz P, Bläss S.
Molecular signatures and new candidates to target the pathogenesis of rheumatoid arthritis. PubMed:20858714

Sample attribute(s):
Material Type
2 recorded
synthetic_RNA total_RNA
1 recorded
synovial tissue
15 recorded
69, 64, 75, 58 years 58, unknown years 51, 84, 74 years 63 years 58, 77 years 86 years 32, 47, 75 years 69 years 45, 81 years 46, unknown years 49 years 44 years 58, 58, 57, unknown years 60, 77 years 68 years
2 recorded
male unknown sex
3 recorded
Healthy_control_subjects rheumatoid arthritis osteoarthritis
sample type
2 recorded
postmortem Surgical excision sample
1 recorded
15 recorded
pooled material donor 1 pooled material donor 5 pooled material RA B individual sample RA z pooled material OA B individual sample OA x pooled material donor 3 individual sample OA y pooled material RA A pooled material donor 4 individual sample RA y individual sample RA x pooled material donor 2 pooled material OA A individual sample OA z
1 recorded
Homo sapiens
2 recorded
female male
Contact(s): Ute Ungethuem
Release Date: 11/11/2007
Submission Date:
Metadata Downloads Download Study Metadata as ISAtabDownload Study Metadata as ISAtab
Assay Downloads
transcription profiling using DNA microarray
15 assays