| Title: |
Transcriptional profiling of synovial tissues from rheumatoid arthritis patients vs. normal controls. [original title: RAvs.ND]
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| Organism(s): |
Homo sapiens
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| Description: |
4 samples each of RA and normal synovial tissue. 6 of the 8 samples are actually pooled material from 2-4 patients with the same condition. When possible the age, sex, and list of current medications are indicated for each patient in each sample; current medications are listed by class as NSAID, DMARD, or steroid. Control samples were obtained from cadavers of accident victims. [original description: Rheumatoid arthritis (RA) is a chronic, inflammatory joint disease of unknown etiology and pronounced inter-patient heterogeneity. To characterize RA at the molecular level and to uncover key pathomechanisms, we performed whole-genome gene expression analyses. Synovial tissues from rheumatoid arthritis patients were compared to those from to normal donors. Keywords: repeat sample Rheumatoid in comparison to normal donors were investigated. For both groups samples derived from individual patients and or pools of patients were hybridised.]
|
| Design(s): |
transcription profiling by array
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| Publication(s): |
Ungethuem U, Haeupl T, Witt H, Koczan D, Krenn V, Huber H, von Helversen TM, Drungowski M, Seyfert C, Zacher J, Pruss A, Neidel J, Lehrach H, Thiesen HJ, Ruiz P, Bläss S
Molecular signatures and new candidates to target the pathogenesis of rheumatoid arthritis.
PubMed:20858714
|
| Sample attribute(s): |
|
| steroid treatment sample 1
2
recorded
|
|
|
|
steroid
none
|
| patient condition at biopsy
2
recorded
|
|
|
|
alive
dead
|
| diagnosis
2
recorded
|
|
|
|
rheumatoid arthritis
control condition
|
| sex2
2
recorded
|
|
|
|
female
male
|
| sex3
1
recorded
|
|
|
|
male
|
| NSAID treatment sample 1
2
recorded
|
|
|
|
non-steroidal anti-inflammatory drug
none
|
| tissue
1
recorded
|
|
|
|
synovial
|
| steroid treatment sample 2
2
recorded
|
|
|
|
none
steroid
|
| sex4
1
recorded
|
|
|
|
unknown
|
| organism
1
recorded
|
|
|
|
Homo sapiens
|
| sex1
2
recorded
|
|
|
|
female
male
|
| DMARD treatment sample 1
2
recorded
|
|
|
|
none
antirheumatic drug
|
| DMARD treatment sample 2
2
recorded
|
|
|
|
none
antirheumatic drug
|
| age4
1
recorded
|
|
|
|
unknown year
|
| Label
1
recorded
|
|
|
|
alpha 33P-dCTP
|
| age3
2
recorded
|
|
|
|
64 year
72 year
|
| age2
6
recorded
|
|
|
|
46 year
64 year
69 year
77 year
66 year
58 year
|
| age1
5
recorded
|
|
|
|
65 year
45 year
58 year
68 year
41 year
|
|
| Contact(s): |
Henning Witt Ute UngethuemUte Ungethuem
|
| Release Date: |
12/10/2004
|
| Submission Date: |
|
| Metadata Downloads |
Download Study Metadata as ISAtabDownload Study Metadata as ISAtab
|
| Assay Downloads |
| transcription profiling using DNA microarray
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| 8 assays |
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