| Title: |
Colon biopsies from Crohns patients and healthy controls. Patients report being on a number of NSAIDs and other medicines.
|
| Organism(s): |
Homo sapiens
|
| Description: |
The aim of this study was to investigate differential intestinal gene expression in patients with Crohn's disease (CD) and controls. 172 biopsies from CD and control subjects were studied. Endoscopic biopsies were taken at ileocolonoscopy from five specific anatomical locations including the terminal ileum for RNA extraction. Biopsies from one of four anatomic locations, from healthy controls and treated (with non-biologic standard of care) or untreated CD patients.
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| Design(s): |
transcription profiling by array
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| Experimental factor(s): |
|
| treatment
4
recorded
|
|
|
|
control
not specified
SoC untreated
SoC treated
|
| treatment response
4
recorded
|
|
|
|
not specified
NA
responder
nonresponder
|
| disease
3
recorded
|
|
|
|
not specified
no abnormal phenotype detected
Crohn's
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| anatomic location
5
recorded
|
|
|
|
colon sigmoideum
not specified
colon ascendens
ileum
colon descendens
|
|
| Publication(s): |
Noble CL, Abbas AR, Lees CW, Cornelius J, Toy K, Modrusan Z, Clark HF, Arnott ID, Penman ID, Satsangi J, Diehl L
Characterization of intestinal gene expression profiles in Crohn's disease by genome-wide microarray analysis.
PubMed:20848455
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| Sample attribute(s): |
|
| Material Type
1
recorded
|
|
|
|
total RNA
|
| treatment
3
recorded
|
|
|
|
control condition
SoC untreated
SoC treated
|
| treatment response
3
recorded
|
|
|
|
NA
responder
nonresponder
|
| Label
2
recorded
|
|
|
|
Cy3
Cy5
|
| disease
2
recorded
|
|
|
|
no abnormal phenotype detected
Crohn's
|
| Organism
1
recorded
|
|
|
|
Homo sapiens
|
| anatomic location
4
recorded
|
|
|
|
colon sigmoideum
colon ascendens
ileum
colon descendens
|
| reference
1
recorded
|
|
|
|
Stratagene Universal Human Reference RNA
|
|
| Contact(s): |
Karen Toy Ian PenmanIan ArnottAlexander AbbasHilary ClarkJennine CorneliusAlex AbbasJack SatsangiCharles LeesLauri DiehlZora ModrusanColin Noble
|
| Release Date: |
7/19/2010
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| Submission Date: |
|
| Metadata Downloads |
Download Study Metadata as ISAtabDownload Study Metadata as ISAtab
|
| Assay Downloads |
| transcription profiling using DNA microarray
|
|
| 172 assays |
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