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E-GEOD-3210

Title: A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity
Organism(s): Rattus norvegicus
Description: A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity These data support the publication titled A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity Copyright (c) 2005 by Iconix Pharmaceuticals, Inc. Guidelines for commercial use: http://www.iconixbiosciences.com/guidelineCommUse.pdf replicated drug treatments with controls
Design(s):
Publication(s): Fielden MR, Eynon BP, Natsoulis G, Jarnagin K, Banas D, Kolaja KL
A gene expression signature that predicts the future onset of drug-induced renal tubular toxicity. PubMed:16239200

Sample attribute(s):
Material Type
2 recorded
total_RNA unknown
sex
1 recorded
male
control identifier
160 recorded
87749 86224 18945 86484 84077 82856 86226 80595 83537 84071 86026 87520 15904 85221 87975 81960 86794 82076 81887 81890 85099 86227 85107 82572 80593 87052 82075 87523 85223 82074 81888 18438 16918 82079 17201 85101 82862 86483 82574 18947 87055 87617 86027 85219 82077 85109 85104 80807 83542 15902 82576 87874 86711 16736 16724 86478 87250 86485 86375 84076 16720 85103 16913 87056 86220 87956 87268 82863 87240 82578 83986 82579 86029 86721 86221 81958 19184 81895 82078 80685 87234 86738 16161 86731 16369 83540 82858 86481 80810 87535 87057 19181 87949 80684 85108 17741 87271 86373 16054 16398 82861 87774 83539 82577 87580 82080 87546 83534 85222 86480 87621 86715 16392 87612 81891 16485 16088 87940 81896 80804 86479 82859 87024 81889 18943 80591 81886 87275 85100 85220 84072 80590 16474 80416 80812 83541 87960 16129 81959 87516 86486 84075 19176 82081 80808 82082 82573 80806 85106 87542 86025 87051 16475 87592 82575 87001 19080 87289 87905 86225
treatment
87 recorded
control condition (6-methoxy-2-naphthyl)acetic acid tenidap indinavir gliclazide cytarabine amikacin oxaliplatin tetrachloromethane cortisol atorvastatin captopril carboplatin sodium aurothiomalate vitamin D2 diazepam amitriptyline ethylene glycol candesartan fluvastatin finasteride cortisone zomepirac bromobenzene 17beta-estradiol bacitracin dexibuprofen sulfinpyrazone transplatin daunorubicin calciol clindamycin lovastatin gadopentetate dimeglumine cisplatin allopurinol valacyclovir idarubicin lincomycin 6-azauridine rifapentine N,N-dimethylformamide valproic acid 3,3',5-triiodo-L-thyronine thiamphenicol lead diacetate 1,8-cineole diclofenac cobalt dichloride bisphenol A clofibrate sirolimus azathioprine gemfibrozil tobramycin 4-nonylphenol oxfendazole roxarsone amiodarone leflunomide doxorubicin cadmium dichloride fenofibrate all-trans-retinoic acid betahistine ramipril cromoglycic acid celecoxib N-nitrosodiethylamine acetylsalicylic acid netilmycin antipyrine acarbose sulfadimethoxine ketoprofen cyclosporin A sulfamethoxazole glycine lisinopril gentamycin bithionol enrofloxacin amprenavir rifabutin ethanol zileuton benazepril
vehicle
5 recorded
CORN OIL CMC SALINE WATER PEG400
organism
1 recorded
Rattus norvegicus
dose in mg per kg per day
62 recorded
N/A 360 75 1000 1500 487 160 8 400 56 300 1750 5 15 710 352 1300 94 800 206 11 439 150 380 239 269 0.5 1 161 125 175 88 4 1200 1400 850 0.1 2 930 3.5 10 610 500 60 54 700 40 200 147 215 7 263 34 375 2000 1100 20.4 70 333 600 6000 450
replicate number
5 recorded
1 3 2 4 5
duration of exposure
7 recorded
3 day 0.25 day 5 day 1 day 7 day 14 day 28 day
organ
1 recorded
kidney
control samples
8 recorded
18943, 18945, 18947, 19080, 19176, 19181, 19184, 80416, 80590, 80591, 80593, 80595, 80684, 80685, 80804, 80806, 80807, 80808, 80810, 80812 83986, 84071, 84072, 84075, 84076, 84077, 85099, 85100, 85101, 85103, 85104, 85106, 85107, 85108, 85109, 85219, 85220, 85221, 85222, 85223 86711, 86715, 86721, 86731, 86738, 86794, 87001, 87024, 87051, 87052, 87055, 87056, 87057, 87234, 87240, 87250, 87268, 87271, 87275, 87289 86025, 86026, 86027, 86029, 86220, 86221, 86224, 86225, 86226, 86227, 86373, 86375, 86478, 86479, 86480, 86481, 86483, 86484, 86485, 86486 15902, 15904, 16054, 16088, 16129, 16161, 16369, 16392, 16398, 16474, 16475, 16485, 16720, 16724, 16736, 16913, 16918, 17201, 17741, 18438 81886, 81887, 81888, 81889, 81890, 81891, 81895, 81896, 81958, 81959, 81960, 82074, 82075, 82076, 82077, 82078, 82079, 82080, 82081, 82082 87516, 87520, 87523, 87535, 87542, 87546, 87580, 87592, 87612, 87617, 87621, 87749, 87774, 87874, 87905, 87940, 87949, 87956, 87960, 87975 82572, 82573, 82574, 82575, 82576, 82577, 82578, 82579, 82856, 82858, 82859, 82861, 82862, 82863, 83534, 83537, 83539, 83540, 83541, 83542
route
4 recorded
gavage intravenous injection intraperitoneal injection subcutaneous injection
Label
1 recorded
1
Contact(s): Deborah BanasBarrett EynonMark FieldenMark FieldenGeorges NatsoulisKyle KolajaKurt Jarnagin
Release Date: 11/30/2005
Submission Date:
Metadata Downloads Download Study Metadata as ISAtabDownload Study Metadata as ISAtab
Assay Downloads
transcription profiling using DNA microarray
540 assays