| Title: |
Expression profiling of peripheral blood cells from patients with coronary artery disease. All patients were treated chronically with aspirin and the antiplatelet drug clopidogrel (Plavix). [original title: Expression data for pharmacogenomics antiplatelet therapy]
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| Organism(s): |
Homo sapiens
|
| Description: |
26 male patients were taking 100 mg/day aspirin and 75 mg/day clopidogrel. Patients were classified as responder, partial responder, or non-responder to each drug, and they were scored for age (range: 38-79), BMI, ARU, and PRU. [original description, slightly edited: Antiplatelet therapy is the most important treatment to reduce the risk of developing recurrent thrombosis and to prevent progression to a complete occlusion of coronary arterial disease (CAD) patients after percutaneous coronary intervention. The aim of this study was to investigate the relationship between response to antiplatelet drugs and global mRNA gene expression in peripheral blood cells (PBC) in patients with coronary arterial disease (CAD). All patients were treated chronically with acetylsalicylic acid (ASA, aspirin; 100 mg/day) and clopidogrel (cf. Plavix; 75 mg/day). Blood samples were drawn before percutaneous coronary intervention (PCI) to evaluate platelet reactivity by VerifyNow ASA and P2Y12 assays, and mRNA expression was measured by Affymetrix GeneChip Human Exon 1.0 ST array.]
|
| Design(s): |
transcription profiling by array
|
| Experimental factor(s): |
|
| response
10
recorded
|
|
|
|
partial responder clopidogrel and partial responder ASA
responder clopidogrel and non responder ASA
non responder clopidogrel and non responder ASA
non responder clopidogrel and partial responder ASA
partial responder clopidogrel and responder ASA
non responder clopidogrel and responder ASA
non responder clopidogrel and partial responder ASA
partial responder clopidogrel and non responder ASA
responder clopidogrel and partial responder ASA
responder clopidogrel and responder ASA
|
| other drug response
3
recorded
|
|
|
|
partial responder to clopidogrel
responder to clopidogrel
non-responder to clopidogrel
|
| aru value
22
recorded
|
|
|
|
400
381
423
441
390
415
446
376
380
539
490
392
398
410
384
421
409
505
467
548
474
452
|
| other drug
1
recorded
|
|
|
|
clopidogrel
|
| NSAID
1
recorded
|
|
|
|
acetylsalicylic acid
|
| bmi
9
recorded
|
|
|
|
29
37
32
27
24
28
30
25
31
|
| pru value
24
recorded
|
|
|
|
198
242
151
268
333
260
190
376
40
113
146
176
134
248
186
226
237
305
265
141
246
249
251
153
|
| age
18
recorded
|
|
|
|
54
57
43
68
56
74
60
58
66
39
65
67
62
79
53
38
64
49
|
| NSAID response
3
recorded
|
|
|
|
partial responder to aspirin
non-responder to aspirin
responder to aspirin
|
|
| Publication(s): |
|
| Sample attribute(s): |
|
| response
9
recorded
|
|
|
|
partial responder clopidogrel and partial responder ASA
responder clopidogrel and non responder ASA
non responder clopidogrel and non responder ASA
non responder clopidogrel and partial responder ASA
partial responder clopidogrel and responder ASA
non responder clopidogrel and responder ASA
partial responder clopidogrel and non responder ASA
responder clopidogrel and partial responder ASA
responder clopidogrel and responder ASA
|
| Material Type
1
recorded
|
|
|
|
total RNA
|
| sex
1
recorded
|
|
|
|
male
|
| aru value
22
recorded
|
|
|
|
400
381
423
441
390
415
446
376
380
539
490
392
398
410
384
421
409
505
467
548
474
452
|
| bmi
9
recorded
|
|
|
|
29
37
32
27
24
28
30
25
31
|
| pru value
24
recorded
|
|
|
|
198
242
151
268
333
260
190
376
40
113
146
176
134
248
186
226
237
305
265
141
246
249
251
153
|
| age
18
recorded
|
|
|
|
54
57
43
68
56
74
60
58
66
39
65
67
62
79
53
38
64
49
|
| organism part
1
recorded
|
|
|
|
peripheral blood cell
|
| Label
1
recorded
|
|
|
|
biotin
|
| organism
1
recorded
|
|
|
|
Homo sapiens
|
|
| Contact(s): |
Andres Iñiguez Marisol BravoAndre LuchessiAmanda SousaGuillermo BastosAndré LuchessiVivian SilbigerDebora CavichioliAngel CarracedoRosario HirataMaria BriónLidio Lima-NetoMario Hirata
|
| Release Date: |
9/15/2012
|
| Submission Date: |
|
| Metadata Downloads |
Download Study Metadata as ISAtabDownload Study Metadata as ISAtab
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| Assay Downloads |
| transcription profiling using DNA microarray
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| 26 assays |
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