The BioInvestigationIndex (BII)

Title:

Expression data from intestinal mucosa of patients with ulcerative colitis. 12 of 43 patients are taking the NSAID mesalazine (aka 5-ASA, 5-aminosalicylic acid, mesalamine).

Organism(s):

Homo sapiens

Description:

Patients are scored for extent and duration (evolution) of disease, plus age and sex. [original description: Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with periods of active disease followed by remission. We performed a whole-genome transcriptional analysis of colonic biopsies from patients with histologically active and inactive UC, as well as non-inflammatory controls. Ulcerative colitis patients and non-inflammatory controls were collected for RNA extraction and hybridization on Affymetrix microarrays. Inclusion criteria for UC patients were: age between 18 and 65, diagnosis of UC established at least 6 months before inclusion and exclusion of concomitant infection. Active disease was defined by endoscopic and histologic score: Mayo sub score >=2 and MATTS >=3 respectively . Inactive disease was also defined by endoscopic and histologic score: Mayo sub score =0 and MATTS <=2 respectively, and a remission state for a minimum of 5 month prior to biopsy collection, and remained inactive for at least 6 months after. Uninvolved mucosa from patients with active UC was defined as a colonic segment with completely normal endoscopic appearance, normal histology, and absence of any previous evidence of active disease. Finally, a total of 43 biopsies were analyzed: 13 healthy controls, 8 inactive UC, 7 non-involved active UC and 15 involved active UC.]

Design(s):

transcription profiling by array

Experimental factor(s):

age years 23 recorded
40 50 38 41 34 36 30 47 63 33 39 53 20 43 45 60 62 22 51 55 54 58 46
sex 2 recorded
female male
disease extension 3 recorded
Left sided ulcerative colitis no disease Ulcerative pancolitis
evolution time years 15 recorded
13 -- 15 3 1 7 10 8 14 29 4 6 2 not specified 22
organ 1 recorded
colon
treatment 5 recorded
mesalamine -- azathioprine Systemic steroids none
disease state 3 recorded
active no disease remission

Publication(s):

Planell N, Lozano JJ, Mora-Buch R, Masamunt MC, Jimeno M, Ords I, Esteller M, Ricart E, Piqu JM, Pans J, Salas A
Transcriptional analysis of the intestinal mucosa of patients with ulcerative colitis in remission reveals lasting epithelial cell alterations. PubMed:23135761

Sample attribute(s):

Material Type 1 recorded
total RNA
age years 23 recorded
40 50 38 41 34 36 30 47 63 33 39 53 20 43 45 60 62 22 51 55 54 58 46
sex 2 recorded
female male
disease extension 3 recorded
Left sided ulcerative colitis no disease Ulcerative pancolitis
evolution time years 14 recorded
13 -- 15 3 1 7 10 8 14 29 4 6 2 22
Label 1 recorded
biotin
organism 1 recorded
Homo sapiens