| Title: |
Transcription profiling of human synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients
|
| Organism(s): |
Homo sapiens
|
| Description: |
Some patients are taking NSAIDs, and some are not. [original description: mRNA expression levels in synovial fibroblasts in 6 rheumatoid arthritis patients versus 6 osteoarthritis patients. Experiment Overall Design: Synovial tissue was obtained from open joint replacement surgery or Experiment Overall Design: arthroscopic synovectomy. Patients with RA or OA (n = 6 each for gene expression analysis and further patients for validation experiments) were classified according to the ACR criteria.]
|
| Design(s): |
disease_state_design, transcription profiling by array
|
| Experimental factor(s): |
|
| NSAID treatment
2
recorded
|
|
|
|
non-steroidal anti-inflammatory drug
none
|
| methotrexate treatment
2
recorded
|
|
|
|
none
methotrexate
|
| diseasestate
2
recorded
|
|
|
|
rheumatoid arthritis
osteoarthritis
|
| steroid treatment
2
recorded
|
|
|
|
none
steroid
|
|
| Publication(s): |
Geurts J, Vermeij EA, Pohlers D, Arntz OJ, Kinne RW, van den Berg WB, van de Loo FA.
A novel Saa3-promoter reporter distinguishes inflammatory subtypes in experimental arthritis and human synovial fibroblasts.
PubMed:21474483
Dirk Pohlers, Andreas Beyer, Dirk Koczan, Thomas Wilhelm, Hans-Jürgen Thiesen, Raimund W Kinne
Constitutive upregulation of the transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts.
PubMed:17594488
|
| Sample attribute(s): |
|
| Material Type
2
recorded
|
|
|
|
synthetic_RNA
total_RNA
|
| CellType
1
recorded
|
|
|
|
synovial fibroblast
|
| age
10
recorded
|
|
|
|
62 years
66 years
68 years
71 years
61 years
72 years
65 years
73 years
56 years
67 years
|
| DiseaseState
2
recorded
|
|
|
|
rheumatoid arthritis
osteoarthritis
|
| ClinicalInformation
4
recorded
|
|
|
|
treatment with NSAID
no concurrent treatment
treatment with MTX
treatment with NSAID and steroids
|
| Label
1
recorded
|
|
|
|
biotin
|
| Individual
12
recorded
|
|
|
|
88
77
73
118
90
74
108
87
102
115
96
81
|
| organism
1
recorded
|
|
|
|
Homo sapiens
|
| Sex
2
recorded
|
|
|
|
female
male
|
|
| Contact(s): |
Andreas Beyer
|
| Release Date: |
4/28/2009
|
| Submission Date: |
|
| Metadata Downloads |
Download Study Metadata as ISAtabDownload Study Metadata as ISAtab
|
| Assay Downloads |
| transcription profiling using DNA microarray
|
|
| 12 assays |
|
|
|
|
