Title: Transcription profiling of human synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients
Organism(s): Homo sapiens
Description: Some patients are taking NSAIDs, and some are not. [original description: mRNA expression levels in synovial fibroblasts in 6 rheumatoid arthritis patients versus 6 osteoarthritis patients. Experiment Overall Design: Synovial tissue was obtained from open joint replacement surgery or Experiment Overall Design: arthroscopic synovectomy. Patients with RA or OA (n = 6 each for gene expression analysis and further patients for validation experiments) were classified according to the ACR criteria.]
Design(s): disease_state_design, transcription profiling by array
Experimental factor(s):
NSAID treatment
2 recorded
non-steroidal anti-inflammatory drug none
methotrexate treatment
2 recorded
none methotrexate
2 recorded
rheumatoid arthritis osteoarthritis
steroid treatment
2 recorded
none steroid
Publication(s): Geurts J, Vermeij EA, Pohlers D, Arntz OJ, Kinne RW, van den Berg WB, van de Loo FA.
A novel Saa3-promoter reporter distinguishes inflammatory subtypes in experimental arthritis and human synovial fibroblasts. PubMed:21474483

Dirk Pohlers, Andreas Beyer, Dirk Koczan, Thomas Wilhelm, Hans-Jürgen Thiesen, Raimund W Kinne
Constitutive upregulation of the transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts. PubMed:17594488

Sample attribute(s):
Material Type
2 recorded
synthetic_RNA total_RNA
1 recorded
synovial fibroblast
10 recorded
62 years 66 years 68 years 71 years 61 years 72 years 65 years 73 years 56 years 67 years
2 recorded
rheumatoid arthritis osteoarthritis
4 recorded
treatment with NSAID no concurrent treatment treatment with MTX treatment with NSAID and steroids
1 recorded
12 recorded
88 77 73 118 90 74 108 87 102 115 96 81
1 recorded
Homo sapiens
2 recorded
female male
Contact(s): Andreas Beyer
Release Date: 4/28/2009
Submission Date:
Metadata Downloads Download Study Metadata as ISAtabDownload Study Metadata as ISAtab
Assay Downloads
transcription profiling using DNA microarray
12 assays