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GSE11138

Title: Left anterior descendent (LAD) coronary artery atherosclerotic plaque gene expression
Organism(s): Homo sapiens
Description: Transcriptional profiling of atherosclerotic plaques from the left anterior descendent (LAD) coronary arteries of 8 patients with 75% stenosis. 2-channel microarray analysis; second channel = pooled RNA from 10 control LAD coronary arteries without plaque. Each slide was scanned three times at low, medium and high sensitivity, plus technical replicates. See original GEO entry and Table 1 from paper for details on control patients. Inferred comorbidities shown are inferred from drug types.
Design(s):
Publication(s): Cagnin S, Biscuola M, Patuzzo C, Trabetti E, Pasquali A, Laveder P, Faggian G, Iafrancesco M, Mazzucco A, Pignatti PF, Lanfranchi G.
Reconstruction and functional analysis of altered molecular pathways in human atherosclerotic arteries. PubMed:19134193

Sample attribute(s):
control
1 recorded
condition
aspirin
1 recorded
acetylsalicylic acid
sex
3 recorded
male 6M/4F female
notable_comorbidities_or_history
4 recorded
hypothyroidism Cholecystectomy pulmonary hypertension nephrolithiasis
pathology
2 recorded
coronary stenosis dilated cardiomyopathy
tissue
1 recorded
Left anterior descendent (LAD) coronary artery
BTO_tissue
1 recorded
coronary artery
FMA tissue
1 recorded
Anterior interventricular branch of left coronary artery
age
7 recorded
68 year 41-63, aver 54.7 year 50 year 66 year 42 year 64 year 53 year
inferred_comorbidity
2 recorded
hypertension Hypercholesterolemia
drug_type_1
1 recorded
Anti-Arrhythmia Agents
Label
2 recorded
Cy5 Cy3
plaque
1 recorded
carotid atherosclerotic
index_of_cardiovascular_risk ICR
7 recorded
5.2 dimensionless unit 3.2-4.7, average 4.0 dimensionless unit 5 dimensionless unit 4.6 dimensionless unit 5.3 dimensionless unit 4.9 dimensionless unit 5.1 dimensionless unit
drug_type_5
1 recorded
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Patient_description
34 recorded
Patient 8 (Technical replicate A) Pooled control samples from 10 patients Patient 1 (Biological replicate B) Patient 3 (Technical replicate) Patient 2 (Technical replicate A) Patient 6 (Technical replicate) Patient 5 (Technical replicate) Patient 5 Patient 2 biological replicate (B) Patient 2 Patient 8 Biological replicate (B) Patient 6 Patient 6 (Techincal replicate) Patient 4 Patient 4 technical replicate Patient 1 (Biological replicate Ex1 and Ex2) Patient 1 (A) Patient 1 (Technical replicate A) Patient 2 (Biological replicate B) Patient 8 (Technical replicate B) Patient 3 Patient 7 Patient 7 (Technical replicate) Patient 1 (Ex 3 technical replicate) Patient 1 (Technical replicate B) Patient 1 (Technical replicate Ex1) Patient 2 (A) Patient 4 (Technical replicate) Patient 8 (A) Patient 1 Biological replicate B Patient 2 (Technical replicate B) Patient 1 Patient 2 Biological replicate (B) Patient 8 A
Organism
1 recorded
Homo sapiens
drug_type_4
1 recorded
Antihypertensive Agents
drug_type_3
1 recorded
anticoagulant
drug_type_2
1 recorded
diuretic
Contact(s):
Release Date: 1/16/2009
Submission Date:
Metadata Downloads Download Study Metadata as ISAtabDownload Study Metadata as ISAtab
Assay Downloads
transcription profiling using DNA microarray
132 assays