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Welcome to the data repository for the Personalized NSAID Therapeutics Consortium (PENTACON). Here you will find curated datasets profiling model systems' response to nonsteroidal anti-inflammatory drugs. The repository is keyword-searchable (i.e. "celecoxib", "indomethacin", "liver", etc.) and individual datasets are downloadable as either ISA-TAB formatted meta-data or raw/processed data.
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60 studies containing 11273 assays

1_jhlab-rnaseq1View record
Homo sapiens
HT-Seq profiling of HASMCs treated with NSAIDS and induced with IL-1B
60 transcription profiling using nucleotide sequencing

E-GEOD-424View record
Rattus norvegicus
Transcription profiling time series of the response of Rattus norvegicus colon carcinoma cell line CC531 to treatment with butyrate or aspirin
12 transcription profiling using DNA microarray

E-GEOD-1919View record
Homo sapiens
Transcriptional profiling of patients with osteoarthritis or rheumatoid arthritis, compared to normal controls. Patients are taking a mixture of NSAIDs, DMARDs (disease-modifying antirheumatic drugs), and steroids. Some samples are pools.[original title: Transcription profiling of human synovial samples from patients with osteoarthritis, rheumatoid arthritis vs controls treated with various drug regimes to characterise RA at the molecular level and to uncover key pathomechanisms]
15 transcription profiling using DNA microarray

E-GEOD-2053View record
Homo sapiens
Transcriptional profiling of synovial tissues from rheumatoid arthritis patients vs. normal controls. [original title: RAvs.ND]
8 transcription profiling using DNA microarray

E-GEOD-2676View record
Mus musculus
Transcriptional profiling of mouse synovial fibroblasts treated with indomethacin or iloprost [original title: Transcription profiling of synovial mouse fibroblast activated by IL-1beta effect of prostacyclin signaling]
4 transcription profiling using DNA microarray

E-GEOD-2950View record
Mus musculus
Transcriptional profiling of mouse ears exposed to the irritant sulfur mustard with or without drug (including indomethacin) pre-treatment. [original title: Transcription profiling of mouse ears exposed to sulfur mustard alone, sulfur mustard preceded by drug treatment, or vehicle compounds to identify gene expression changes that correlate with compound efficacy]
107 transcription profiling using DNA microarray

E-GEOD-3210View record
Rattus norvegicus
A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity
540 transcription profiling using DNA microarray

E-GEOD-3589View record
Homo sapiens
Transcription profiling of human umbilical vein endothelial cells (HUVEC) treated with thrombin and leukotriene D4 (LTD4) with ethanol controls to delineate
21 transcription profiling using DNA microarray

E-GEOD-3737View record
Homo sapiens
Transcription profiling of human prostate cancer cells treated with arachidonic acid reveals induction of 11 genes that are regulated by NFkappaB
8 transcription profiling using DNA microarray

E-GEOD-5258View record
Homo sapiens
Transcription profiling of human cell lines freely cycling treated with 164 distinct small molecules - Broad Connectivity Map CMAP Set 1
564 transcription profiling using DNA microarray

E-GEOD-7584View record
Rattus norvegicus
Transcription profiling of rat intestinal epithelial IEC-6 cells treated with non-steroidal anti-inflammatory agents to investigate gastrointestinal toxicity of NSAIDs
14 transcription profiling using DNA microarray

E-GEOD-7669View record
Homo sapiens
Transcription profiling of human synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients
12 transcription profiling using DNA microarray

E-GEOD-8251View record
Rattus norvegicus
Transcriptional profiling of rat liver after drug treatment [original title: Non-genotoxic Hepatocarcinogens]
990 transcription profiling using DNA microarray

E-GEOD-8650View record
Homo sapiens
Transcription profiling of PBMCs from patients with several autoimmune inflammatory diseases or similar disorders and healthy controls. Some patients are on Celebrex or steroids. [original title: Transcription profiling of human blood leukocytes to diagnose systemic onset juvenile idiopathic arthritis and follow IL-1 blockade]
246 transcription profiling using DNA microarray

E-GEOD-8858View record
Rattus norvegicus
Transcriptional profiling of rat liver after exposure to drugs or chemicals (expanded dataset). [original title: Liver Pharmacology and Xenobiotic Response Repertoire]
5312 transcription profiling using DNA microarray

E-GEOD-9820View record
Homo sapiens
Trancriptional profiling of five classes of white blood cells in patients with coronary artery disease. [original title: Circulating Mononuclear Cell Transcriptomes in Patients with Atherosclerotic Coronary Artery Disease]
153 transcription profiling using DNA microarray

E-GEOD-10621View record
Homo sapiens
Transcription profiling of human ciliary smooth muscle cells grown culture with 200 nM of either a prostaglandin E2 receptor subtype EP2 or subtype EP4 selective agonist for 6 hours in comparison to untreated controls. Culture conditions included 100 nM indomethacin.
8 transcription profiling using DNA microarray

E-GEOD-11237View record
Homo sapiens
Transcription profiling of human colorectal adenocarcinoma patients after Celecoxib pre-treatment
23 transcription profiling using DNA microarray

E-GEOD-12021View record
Homo sapiens
Transcription profiling of human rheumatoid arthritis patients to identify inter-individual and gene-specific variance in the synovial membrane
57 transcription profiling using DNA microarray

E-GEOD-12112View record
Rattus norvegicus
Sprague-Dawley rats treated with celecoxib to prevent induced cancer. [original title: Chemoprevention of the hepatocarcinogenesis by celecoxib]
12 transcription profiling using DNA microarray

E-GEOD-12860View record
Homo sapiens
Transcriptional profiling of human knee chondrocytes stimulated with supernatant from synovial fibroblasts treated with NSAIDs or other drugs. [original title: Transcription profiling of human chondrocytes antirheumatic drug response: potential molecular targets to stimulate cartilage regeneration]
20 transcription profiling using DNA microarray

E-GEOD-14442View record
Homo sapiens
Gene expression analysis in gut biopsies of Crohn's Disease patients and patients with Spondylarthropathy
84 transcription profiling using DNA microarray

E-GEOD-14538View record
Homo sapiens
Transcriptional profiling of human Caco2 cells treated with the NSAID mesalazine
2 transcription profiling using DNA microarray

E-GEOD-15308View record
Homo sapiens
Expression profiling of the cell line SSC9 (human squamous carcinoma of the tongue) treated with the NSAID nimesulide and/or cisplatin. [original title: Genomics of oral cancer cells]
11 transcription profiling using DNA microarray

E-GEOD-15799View record
Homo sapiens
Adenocarcinoma cells treated with the NSAID NS-398 [original title: Expression data from NS398-treated and control HT29 colon adenocarcinoma cell line samples]
6 transcription profiling using DNA microarray

E-GEOD-16752View record
Rattus norvegicus
Rat liver. Control vs. Chemical treated: time course
1041 transcription profiling using DNA microarray

E-GEOD-16797View record
Homo sapiens
Transcription profiling of Kawasaki disease patients treated with aspirin and IV immunoglobulins. Some patients were also treated with methylprednisone. [original title: Transcription profiling of Kawasaki disease patients who may benefit from methylprednisolone]
34 transcription profiling using DNA microarray

E-GEOD-18103View record
Mus musculus
Adipocytes desensitized and resensitized to insulin through the combined action of TNF-alpha, aspirin, and troglitazone. [original title: A Gene Expression Signature for Insulin Resistance]
64 transcription profiling using DNA microarray

E-GEOD-18232View record
Homo sapiens
RAS signaling in colon carcinoma: Target gene deregulation and growth control through Y-box-binding protein 1
18 transcription profiling using DNA microarray

E-GEOD-19232View record
Homo sapiens
Human mesenchymal stem cells induced to differentiate by treatment with the NSAID indomethacin and/or other drugs. [original title: miR-335 regulates cell migration and differentiation in human mesenchymal stem cells]
20 transcription profiling using DNA microarray

E-GEOD-19662View record
Rattus norvegicus
Gene expression profiling of rat hepatocytes after a 24h treatment with various drugs and other chemicals. [original title: Identification of biomarkers that distinguish chemical contaminants using a gradient feature selection method]
531 transcription profiling using DNA microarray

E-GEOD-19773View record
Homo sapiens
Gene expression profiling in several types of stem cells; some cells treated with indomethacin in differentiation medium. [original title: DNA methylation in progenitor cells: expression study]
11 transcription profiling using DNA microarray

E-GEOD-20881View record
Homo sapiens
Colon biopsies from Crohns patients and healthy controls. Patients report being on a number of NSAIDs and other medicines.
172 transcription profiling using DNA microarray

E-GEOD-22445View record
Homo sapiens
Mesothelioma cells treated with the NSAID piroxicam and/or the anticancer drug cisplatin [original title: Apoptosis induced by Piroxicam/Cisplatin combined treatment is triggered by p21 in mesothelioma]
18 transcription profiling using DNA microarray

E-GEOD-23742View record
Mus musculus
Gene expression profiling of mouse liver during a diet of fish oil or olive oil with or without indomethacin. [original title: Gene expression data from mouse liver]
4 transcription profiling using DNA microarray

E-GEOD-26080View record
Homo sapiens
Genomic DNA methylation profiling in dust-mite-allergic or aspirin-intolerant patients' CD19+ B lymphocytes. [original title: Epigenetic changes in B lymphocytes associated with house dust mite allergic asthma.]
9 DNA methylation profiling using DNA microarray

E-GEOD-28185View record
Homo sapiens
2 AML (acute myeloid leukemia) cell lines treated with the NSAID diclofenac, vs. control. [original title: The non-steroidal anti-inflammatory drugs Sulindac sulfide and Diclofenac induce apoptosis and differentiation in human acute myeloid leukemia cells through an AP-1 dependent pathway]
8 transcription profiling using DNA microarray

E-GEOD-28628View record
Homo sapiens
Human adipocytes induced to differentiate with indomethacin. [original title: Identification of new genes involved in human adipogenesis and fat storage]
9 transcription profiling using DNA microarray

E-GEOD-29331View record
Saccharomyces cerevisiae
Expression data from diclofenac-treated yeast cells
10 transcription profiling using DNA microarray

E-GEOD-32226View record
Homo sapiens
Expression profiling of peripheral blood cells from patients with coronary artery disease. All patients were treated chronically with aspirin and the antiplatelet drug clopidogrel (Plavix). [original title: Expression data for pharmacogenomics antiplatelet therapy]
26 transcription profiling using DNA microarray

E-GEOD-34112View record
Homo sapiens
Transcriptional profiling of PC3 prostate cancer cells treated with the NSAIDs sulindac or nitrosulindac (aka NO-sulindac, NCX-1102). [original title: Effect of NO-sulindac treatment on hypoxic prostate cancer cells]
16 transcription profiling using DNA microarray

E-GEOD-36010View record
Rattus norvegicus
Expression profiling of rat cerebral cortex after surgical induction of ischemia/infarction; the NSAID meloxicam was used during surgical prep. [original title: mRNA profiles after experimental ischemia]
44 transcription profiling using DNA microarray

E-GEOD-36169View record
Homo sapiens
Expression profiling reveals elevated PTGDS (prostagladin D2 synthase) in bald scalp regions. [original title: Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia]
10 transcription profiling using DNA microarray

E-GEOD-37521View record
Homo sapiens
Dermal and adipose stem cells treated with the NSAID indomethacin and/or other drugs. [original title: RNA-Seq Analysis Reveals Different Dynamics of Differentiation of Human Dermis- and Adipose-derived Stromal Stem Cells]
96 transcription profiling using nucleotide sequencing

E-GEOD-37836View record
Homo sapiens
Time course of gene expression during adipogenesis. Adipogenic induction medium contained indomethacin. [original title: Differentially expressed zinc finger proteins during human adipogenesis]
30 transcription profiling using DNA microarray

E-GEOD-38151View record
human gut metagenome
Xenobiotics shape the physiology and gene expression of the active human gut microbiome
72 transcription profiling using nucleotide sequencing

E-GEOD-38406View record
Homo sapiens
Differential functional effects of Indomethacin along the human fetal intestine
16 transcription profiling using DNA microarray

E-GEOD-38511View record
Homo sapiens
Aspirin Exposure Reveals Novel Genes Associated with Platelet Function and Cardiovascular Events (outpatient cardiology)
26 transcription profiling using DNA microarray

E-GEOD-38713View record
Homo sapiens
Expression data from intestinal mucosa of patients with ulcerative colitis. 12 of 43 patients are taking the NSAID mesalazine (aka 5-ASA, 5-aminosalicylic acid, mesalamine).
43 transcription profiling using DNA microarray

E-GEOD-38988View record
Mus musculus
Cell Intrinsic role of Cox-2 in pancreatic cancer development
8 transcription profiling using DNA microarray

E-GEOD-39192View record
Homo sapiens
Transcriptional profiling of three human melanoma cell lines treated with the NSAID diclofenac and/or the anticancer drug sorafenib. [original title: Synthetic lethal screening with small molecule inhibitors provides a pathway to rational combination therapies for melanoma]
24 transcription profiling using DNA microarray

E-GEOD-42686View record
Homo sapiens
Chip-chip from undifferentiated and neuron-differentiated hMSCs cells with EZH2
4 protein-DNA binding site identification using DNA microarray

E-GEOD-45340View record
Homo sapiens
Combination of celecoxib and sorafenib provides synergistic antiproliferative and proapoptotic effects in human liver cancer cells
4 transcription profiling using DNA microarray

E-GEOD-46451View record
Homo sapiens
Effects of Inflammation and 5-ASA on ex vivo cultured ulcerative colitis biopsies
12 transcription profiling using DNA microarray

E-GEOD-49195View record
Mus musculus
Gene expression profiling of liver tissue from lean (WT) and obese (ob/ob) mice following a chronic exposure of low doses of pharmaceuticals
24 transcription profiling using DNA microarray

E-GEOD-53851View record
Mus musculus
A probiotics strain attenuating the effects of aspirin in the gut
5 transcription profiling using DNA microarray

GSE11138View record
Homo sapiens
Left anterior descendent (LAD) coronary artery atherosclerotic plaque gene expression
132 transcription profiling using DNA microarray

GSE11223View record
Homo sapiens
Colon biopsies from ulcerative colitis patients and healthy controls
404 transcription profiling using DNA microarray

GSE21274View record
Homo sapiens
Expression profiling of genes responding to flurbiprofen enantiomers in HaCaT cells
14 transcription profiling using DNA microarray

GSE36700View record
Homo sapiens
Gene expression profiles in synovial biopsies from patients with arthritis
25 transcription profiling using DNA microarray